(During the nuclear meltdown, Mr. Burns has locked Smithers out of the escape pod)
Smithers: For the love of God, sir! There are two seats!
Mr. Burns: I like to put my feet up.

I don't understand it! There wasn't any nuclear material in that van!

Nuclear Safety Engineer

Nuclear Saftey Engineer: Now, relax, Homer. This is a simulation of your work station and we're going to simulate a power surge in Sector 8.
Homer: What the hell are you talking about?

Mr. Burns: What, how dare you disturb us during nap time!
Lady: We're from the Nuclear Regulatory Comission. This is a surprise test of worker competence.
Mr. Burns: There must be some mistake. Weee... make cookies here. Mr. Burns old fashion good time, extra chewy..
Man: Get the axe!

D'oh! The bee bit my bottom! Now my bottom's big!

Homer

Man: Homer, sign this application, and you're a shoe-in.
Homer: Hahaha, that dog has somebody's ham. Now this I gotta see!

Woohoo! I'm a college man! I won't need my high school diploma any more! (sets diploma on fire) I am so smart, I am so smart, S-M-R-T... I mean S-M-A-R-T.

Homer

Homer: My first day of college.. I wish my father was alive to see this!
Grampa: Hey!
Homer: How long have you been back there?
Grampa: Three days...

Dean: Hello..
Homer: Hello, Dean! You're a stupid head!
Dean: Homer is that you?

Bart: Gentlemen, I propose we kidnap Sir-Oinks-A-Lot..
Homer: And then we roll him up in a carpet and throw him off a bridge!

Mrs. Simpson, we all have nose bleeds.

Doug

Marge: An A+, how did you do it?
Homer: Oh, lets just say I had help from a little magic box!
Marge: You changed your grade with a computer?
Homer: D'oh!

The Simpsons Season 5 Quotes

(Apu returns to work at the Kwik-E-Mart)
Apu: It may not be glamorous, but it's good honest work.
Customer: How much is this quart of milk?
Apu: Twelve dollars.

Groundskeeper Willie:(Singing) When you're alone, and life is getting you lonely, ye can always go, ACK! Doontoon.
Apu: Next