Penny [to Sheldon]: Your food's ready.
Leonard: No, no, what are you doing? He's both happy and quiet. It's like seeing a unicorn and Bigfoot at the same time.

Raj: I think it could be romantic. You know, my parents met at his place of work.
Leonard: Your father's a gynecologist.
Raj: I know. What started as a pap smear turned into a date, which turned into her working there, which turned into marriage, which turned into hatred which continues to this day.

Howard: Wait. Wait. If it wasn't for Indiana Jones, the ark would never have ended up at the warehouse!
Sheldon: (gasps) That's true! He collected and delivered the ark to the proper authorities for filing.
Raj: Like a hero.
All: Yeah! Right! Yes!
Leonard: Although, technically, Indy was supposed to take the ark to a museum to be studied. He couldn't even get that done.
All: Aww.

Sheldon: You've spent time with Amy. Can you think of anything she's fond of that has a bunch of flaws she hasn't noticed?
Leonard: I've gotta go.

Leonard: They weren't boobies. They were muscles. And, the make-up was green, I was pretending to be the Hulk.
Penny: You were wearing her bra.
Leonard: That was to keep my muscles from sagging!

Penny: Not even the chapter on the breast feeding crisis?
Leonard: It was not a crisis. Apparently, I favored the left one, she got a little lopsided.
Penny: Oh, my God, you still go left!

Penny: Oh, come on. Why? How bad could it be?
Leonard: There-there's chapters about potty training, bed wetting and masturbation. Basically, if something came out of me, she wrote about it!

Sheldon: To the planetarium!
Penny: Let's go!
Leonard: To the Tar Pits!
Bernadette: Let's go!
Amy: There's a Neil Diamond concert next month.
Howard: Let's go!

I have to hit the head. That's what us salty seadogs say when we have to go pee-pee.

Leonard: I didn't tell Sheldon so we could have a few days alone.
Penny: Oh, that is so romantic.
Leonard: Uh, sure, that's why I did it.

Penny: I love you.
Leonard: I love you, too.

Penny: Oh, I don't know. Remember what happened when I took care of your goldfish?
Leonard: Well, flush Sheldon down the toilet and get me a new one.

TBBT Quotes

I was expecting applause but I suppose stunned silence is equally appropriate.

Sheldon

Sheldon: Nothing more fun than a paradigm shifting evening of science.
Penny: (to Leonard) And you thought it was soaping me up in the shower.