Sheldon: I want you to know that I'm genuinely concerned about your well-being.
Leonard: Thank you.
Sheldon: You're welcome. But it's still no reason to have your feet in my spot.

Leonard: Have you considered telling her your feelings?
Sheldon: Leonard, I'm a physicist, not a hippie.
Leonard: Well let me see if I can explain your situation using physics. What would you be if you were attached to another object by an incline plane, wrapped helicly around an axis.
Sheldon: Screwed.
Leonard: There you go.

Leonard: How can you have a girlfriend you can't even speak to women?
Raj: Two words: deaf chick. It doesn't matter if i can't talk cause she can't hear me.
Leonard: What?
Raj: That's what she said.

If they took all the money trying to make a decent Hulk movie, they could probably just make an actual Hulk.

Sheldon: Why on earth are you telling me all this?
Leonard: Sometimes you movements are so lifelike I forget you're not a real boy.

Leonard: Why would you want a glow-in-the-dark ant farm?
Sheldon: They do some of their best work at night.

Wolowitz: I love watching Raj and Sheldon try to work together.
Leonard: Yeah, it's like if Alien and Predator decided to go partners in a Jamba Juice.

Leonard: ...and when she died, they ate her.
Sheldon: You don't have to sell me on cats, I'm already a fan!

Leonard: So, this is nice. First time we've all gotten together to eat.
Amy (to Sheldon): You're right. He's a festival of humdrum chitchat.
Leonard: Okay, that's all I got. Howard, you're up.
Wolowitz: Um, tell us about your work, Amy.
Amy: I doubt you'd understand. Sheldon tells me you only have a master's degree.
Wolowitz: Raj, do you have any questions for Amy?

Leonard: Did you guys see the paper in the American Physics Journal on supersolids? It's pretty interesting. This guy's working from a hypothesis which ...
Raj: Spoiler alert! Spoiler alert!
Leonard: What?
Raj: Don't ruin it for me, man! I printed out a PDF to read on the potty.

Leonard: Amy is judgmental, sanctimonious, and frankly just obnoxious
Sheldon: So?
Leonard: So we already have you for all that.

Leonard: Penny, Steve Wozniack was one of the co-founders of Apple computer. He and Steve Jobs...
Penny: Yeah. I know who he is. I watch Dancing With the Stars.

TBBT Quotes

You can't ruin a friendship with sex that's like trying to ruin ice cream with chocolate sprinkles.

Raj

Sheldon: Even the dung beetle chooses to plot its course by using the Milky Way.
Raj: Is that true?
Sheldon: Everything I say is true. Now, of course, the dung beetle also enjoys eating fece, living in feces and making little balls out of feces. So, pick and choose which aspects of its lifestyle you want to embrace.