Sheldon: I want you to know that I'm genuinely concerned about your well-being.
Leonard: Thank you.
Sheldon: You're welcome. But it's still no reason to have your feet in my spot.

Leonard: Have you considered telling her your feelings?
Sheldon: Leonard, I'm a physicist, not a hippie.
Leonard: Well let me see if I can explain your situation using physics. What would you be if you were attached to another object by an incline plane, wrapped helicly around an axis.
Sheldon: Screwed.
Leonard: There you go.

Leonard: How can you have a girlfriend you can't even speak to women?
Raj: Two words: deaf chick. It doesn't matter if i can't talk cause she can't hear me.
Leonard: What?
Raj: That's what she said.

If they took all the money trying to make a decent Hulk movie, they could probably just make an actual Hulk.

Sheldon: Why on earth are you telling me all this?
Leonard: Sometimes you movements are so lifelike I forget you're not a real boy.

Leonard: Why would you want a glow-in-the-dark ant farm?
Sheldon: They do some of their best work at night.

Wolowitz: I love watching Raj and Sheldon try to work together.
Leonard: Yeah, it's like if Alien and Predator decided to go partners in a Jamba Juice.

Leonard: ...and when she died, they ate her.
Sheldon: You don't have to sell me on cats, I'm already a fan!

Leonard: So, this is nice. First time we've all gotten together to eat.
Amy (to Sheldon): You're right. He's a festival of humdrum chitchat.
Leonard: Okay, that's all I got. Howard, you're up.
Wolowitz: Um, tell us about your work, Amy.
Amy: I doubt you'd understand. Sheldon tells me you only have a master's degree.
Wolowitz: Raj, do you have any questions for Amy?

Leonard: Did you guys see the paper in the American Physics Journal on supersolids? It's pretty interesting. This guy's working from a hypothesis which ...
Raj: Spoiler alert! Spoiler alert!
Leonard: What?
Raj: Don't ruin it for me, man! I printed out a PDF to read on the potty.

Leonard: Amy is judgmental, sanctimonious, and frankly just obnoxious
Sheldon: So?
Leonard: So we already have you for all that.

Leonard: Penny, Steve Wozniack was one of the co-founders of Apple computer. He and Steve Jobs...
Penny: Yeah. I know who he is. I watch Dancing With the Stars.

TBBT Quotes

Penny: Hey, Sheldon, did you change your Wi-Fi password again?
Sheldon: Yes, it's "Penny, get your own Wi-Fi." No spaces.

Sheldon: Why do you have the Chinese character for "soup" tattooed on your right buttock?
Penny: It's not "soup," it's "courage."
Sheldon: No it isn't. But I suppose it does take courage to demonstrate that kind of commitment to soup.
Penny: How'd you see it? You said you wouldn't look.
Sheldon: Sorry. As I told you, the hero always peeks.