Sheldon: I want you to know that I'm genuinely concerned about your well-being.
Leonard: Thank you.
Sheldon: You're welcome. But it's still no reason to have your feet in my spot.

Leonard: Have you considered telling her your feelings?
Sheldon: Leonard, I'm a physicist, not a hippie.
Leonard: Well let me see if I can explain your situation using physics. What would you be if you were attached to another object by an incline plane, wrapped helicly around an axis.
Sheldon: Screwed.
Leonard: There you go.

Leonard: How can you have a girlfriend you can't even speak to women?
Raj: Two words: deaf chick. It doesn't matter if i can't talk cause she can't hear me.
Leonard: What?
Raj: That's what she said.

If they took all the money trying to make a decent Hulk movie, they could probably just make an actual Hulk.

Sheldon: Why on earth are you telling me all this?
Leonard: Sometimes you movements are so lifelike I forget you're not a real boy.

Leonard: Why would you want a glow-in-the-dark ant farm?
Sheldon: They do some of their best work at night.

Wolowitz: I love watching Raj and Sheldon try to work together.
Leonard: Yeah, it's like if Alien and Predator decided to go partners in a Jamba Juice.

Leonard: ...and when she died, they ate her.
Sheldon: You don't have to sell me on cats, I'm already a fan!

Leonard: So, this is nice. First time we've all gotten together to eat.
Amy (to Sheldon): You're right. He's a festival of humdrum chitchat.
Leonard: Okay, that's all I got. Howard, you're up.
Wolowitz: Um, tell us about your work, Amy.
Amy: I doubt you'd understand. Sheldon tells me you only have a master's degree.
Wolowitz: Raj, do you have any questions for Amy?

Leonard: Did you guys see the paper in the American Physics Journal on supersolids? It's pretty interesting. This guy's working from a hypothesis which ...
Raj: Spoiler alert! Spoiler alert!
Leonard: What?
Raj: Don't ruin it for me, man! I printed out a PDF to read on the potty.

Leonard: Amy is judgmental, sanctimonious, and frankly just obnoxious
Sheldon: So?
Leonard: So we already have you for all that.

Leonard: Penny, Steve Wozniack was one of the co-founders of Apple computer. He and Steve Jobs...
Penny: Yeah. I know who he is. I watch Dancing With the Stars.

TBBT Quotes

Sheldon: Are you still mad about the sperm bank?
Leonard: No!
Sheldon: Do you want to hear an interesting thing about stairs?
Leonard: Not really.
Sheldon: If the height of a single step is off by as little as two millimeters most people will trip.
Leonard: I don't care—two millimeters?! That doesn't seem right.
Sheldon: No, it's true! I did a series of experiments when I was twelve; my father broke his clavicle.

Penny, there's only one cookie with something in the middle that solves life's problems, and that's an Oreo. Or a Nutter Butter, if you're in a pinch.

Sheldon