Lois: Look, Stewie, a note. You know, Mommy doesn't usually read things out of Chris' pocket, she's more respectful then that.
Stewie: Yeah sure, whatever helps you sleep at night, bitch

Chris: Why is everybody acting weird?
Lois: Chris, honey, we know what you did. And I have to say, honestly, I don't approve.
Chris: What I did? Oh, that I lied about my age to get into Indian bingo?
Peter: Uh, no.
Chris: That I had hard gas and pooed myself?
Peter: Close, but still no.
Stewie: How is that close?

Lois: Peter, there's a hooker on the bed!
Peter: Stay perfectly still, Lois, their sight is based on movement.
Hooker: Where'd ya go?

Lois: Honey, what do you say we christen these new sheets, huh?
Peter: Why Lois Griffin, You naughty girl.
Lois: Hahaha, That's me.
Peter: You dirty hustler...you filthy stinky prostitute.
Lois: Okay I get it.
Peter: You foul venereal disease carrying street walking whore.
Lois: That's enough

Peter: Everybody, I got bad news - we've been cancelled.
Lois: Oh, no. Peter, how can they do that?
Peter: Well, unfortunately, Lois, there's just no more room on the schedule. We just gotta accept the fact that Fox has to make room for terrific shows like: Dark Angel, Titus, Undeclared, Action, That 80's Show, Wonderfalls, Fastlane, Andy Richter Controls The Universe, Skin, Girls Club, Cracking Up, The Pits, Firefly, Get Real, Freaky Links, Wanda At Large, Costello, The Lone Gunmen, A Minute With Stan Hooper, Normal, Ohio, Pasadena, Harsh Realm, Keen Eddie, The Street, American Embassy, Cedric The Entertainer, The Tick, Louie, and Greg The Bunny.
Lois: Is there no hope?
Peter: Well, I suppose if ALL those shows go down the tubes we might have a shot

Peter: Lois, this is my new friend Max Weinstein! He's Jewish!
Lois: Ooooooooh, how exotic!

Genie: I am here to grant you three wishes.
Lois: Peter, three wishes. Oh this is so exciting.
Meg: I want a new hat
Chris: I want a new hat
Stewie: I want them to have new hats!

Peter: Lois, I'm packing for Kissstock and I can't find my favorite underwear!
Lois: You mean the one with the hole in the left butt cheek from you tore them pulling them up in the airplane bathroom when you had the trots?
Peter: No, the one with the hole in the right butt cheek from when I held it in during the extra-long sunday service mass because I thought blowing gas would offend Jesus, and I let it go in the vestibule, and it sounded like Louis Armstrong?
Lois: Oh. Middle drawer!

Lois: Peter, are you ever gonna forgive me?
Peter: Lois, I am obligated to keep loving you, so I will take my rage out on my own body. Let's go to Denny's.

Lois: Good, I don't have to cook.
Peter: Oh, no, go ahead and cook anyway, Lois, and we'll throw it out. I don't want you to get rusty

Lois: So Meg, did any of the neighbors see Jeff come over?
Meg: Mom! Come one Jeff, let's go in other room.
Lois: Now Meg, no need to get so testes, uh testy. Nuts, I mean crap!

Lois: Hey Brian... you're home early. What happened with your date?
Brian: Same thing that always happens, she was an idiot

Family Guy Quotes

Aunt Margarite [on her video will]: Lois, you were always my favorite niece; I just knew you would find a wonderful man who would make all your dreams come true. But I was wrong.
Peter: And now you're dead. Score one for Peter

But now that you mention it, your face looks like a used condom.

Quagmire