Bernadette: Doesn't he know you have a boyfriend?
Penny: Oh, she doesn't have a boyfriend; she has a Sheldon.

Amy, little vixen. Just working it under all those layers of wool and polyester.

Leonard: No. You always picked and it was always the same. An hour and a half of beach houses in the rain until the woman turns around and realizes love was here all along.
Penny: But, come on, that was a great movie and it starts in ten minutes.

Penny: And,remember he's more afraid of you than you are of him.
Sheldon: That doesn't help.
Penny: No, I was talking to the bird.

Leonard: Star Wars on Blu-ray.
Penny: Haven't you seen that movie like a thousand times?
Leonard: Not on Blu-ray. Only twice on Blu-ray.
Penny: Oh, Leonard.
Leonard: I know, it's high resolution sadness.

It's a rough month when Halloween and PMS hit at the same time.

Oh, they don't always get to ride the roller coaster. Sometimes they only get to spin the teacups.

Penny: Wil Wheaton is Sheldon's mortal enemy.
Amy: Mortal enemy?
Penny: Mm-hmm.
Amy: Sheldon, I know you are a bit of a left-handed monkey wrench but... you really have a mortal enemy?
Sheldon: In fact, I have 61 of them.

Sheldon: The Koothrappalis aren't just rich, they're Richie Rich rich.
Penny: How much is that?
Sheldon: About halfway between Bruce Wayne and Scrooge McDuck.

Okay, so future grief-stricken widow is the one to beat.

I feel like two totally different people. Dr. Jekyyl and Mrs. Whore.

Raj: To quote Shakespeare, "It is better to have loved and lost than to stay home every night and download increasingly shameful pornography."
Penny: Oh, you poor baby!
Raj: What's wrong with me, Penny?
Penny: Nothing! Nothing. You know, if we weren't friends - and you hadn't brought up that creepy pornography story - I'd be on you like the speed of light squared on matter to make energy.

TBBT Quotes

You can't ruin a friendship with sex that's like trying to ruin ice cream with chocolate sprinkles.

Raj

Sheldon: Even the dung beetle chooses to plot its course by using the Milky Way.
Raj: Is that true?
Sheldon: Everything I say is true. Now, of course, the dung beetle also enjoys eating fece, living in feces and making little balls out of feces. So, pick and choose which aspects of its lifestyle you want to embrace.