Sam: Huh.
Dean: Shut it.
Sam: I just said huh.
Dean: I just said shut it.

Dean: Until we get you back on your soul train, I'll be your conscience.
Sam: So you're saying you'll be my Jiminy Cricket.
Dean: Shut up. But yeah you fricken puppet, that's exactly what I'm saying.

You don't know me. You never did, and you never will.

No drinking, no gambling, no pre-marital sex. Dean, they basically just outlawed 90% of your personality.

Dean: Not a word.
Sam: Dude, you just got whaled on by Paris Hilton.

Sam: We landed in some dimension where you're called Jensen Ackles and I'm something called a Jared Padalecki.
Dean: So, what? Now you're Polish?

Dean: Really? Anna?
Castiel: It's true.
Dean: So she's gone all Glenn Close, huh? That's awesome.
Castiel: Who's Glenn Close?
Dean: No one. Just this psycho bitch who likes to boil rabbits.
Sam: So, the... the plan to kill me--would it actually stop Satan?
Dean: No, Sam, come on.
Sam: Cass, what do you think? Does Anna have a point?
Castiel: No. She's a... "Glenn Close."

Sam: It's like Grumpy Old Men.
Dean and Bobby: Shut up, Sam!

Dean: Try uh, Lautner.
Sam: He's a werewolf. How do you even know who that is?
Dean: What are you kidding me? That kid is everywhere. It's a friggen nightmare.

Dean: Who, whoa, whoa, wait? You two know each other?
Crowley: Not in the biblical sense, more of a business relationship I'd say.
Sam: [to Samuel] You're Crowley's bitch.

Dean: So, screw destiny right in the face. I saw we take the fight to them, do it our way.
Sam: Sounds good.

Sam: What's wrong with you? Are you... drunk?
Castiel: No! Yes.
Sam: What the hell happened to you.
Castiel: I found a liquor store.
Sam: And?
Castiel: I drank it.

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean