Sam: What's wrong with you? Are you... drunk?
Castiel: No! Yes.
Sam: What the hell happened to you.
Castiel: I found a liquor store.
Sam: And?
Castiel: I drank it.

Sam: Who would want virgins?
Dean: You've got me. I prefer ladies with experience.

Dean: Who, whoa, whoa, wait? You two know each other?
Crowley: Not in the biblical sense, more of a business relationship I'd say.
Sam: [to Samuel] You're Crowley's bitch.

Dean: Try uh, Lautner.
Sam: He's a werewolf. How do you even know who that is?
Dean: What are you kidding me? That kid is everywhere. It's a friggen nightmare.

Dean: I've decided. I'm going to give Stan my most precious gift.
Sam: Wow. That sounded really creepy coming out of your mouth.

Sam: Dean, enough!
Dean: What?
Sam: You just punched a Cupid!
Dean: I punched a dick!

Sam: You still crazy?
Dean: Not any more than usual.

Sam: Get out of me.
Dean: You're such a prude. Come on.

I am doing all I can, to slightly lessen the spread of... of genital herpes. And that's a good thing.

Dean: You know I finally get why you and dad butted heads so much. You two are practically the same person. I mean I worshipped the guy, y'know: I dressed like him, I acted like him, I listened to the same music. But you are more like him than I will ever be. I see that now.
Sam: I'll take that as a compliment.
Dean: You can take it any way you want.

Dean: What exactly are we gonna march up there and tell 'em?
Sam: Uh, the truth.
Dean: What, that their sons are back from the future to save them from an angel gone Terminator? Come on, those movies haven't even come out yet.

Dean: Let me get this straight. Your, uh, ultimate hero was not only a short man in diapers, but he was a fruitarian.
Sam: That's not the point.
Dean: That is good. Even for you, that is good

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean