Sheldon: What are you doing now?
Howard: Making a straw.
Sheldon: Why?
Howard: So I can shoot you with a spitball.
Sheldon: You're not going to do that, and I'll tell you why. This is an institution of higher learning, I am your professor, and you're going to treat me with the prop... You shot your spit in my mouth!
Howard: Is that gonna be on the test? Because I don't think I could do that again.

Sheldon: What are you doing?
Howard: If you're gonna be a crappy teacher, then I'm gonna be a crappy student.

I can't believe I have to waste my time babysitting a bunch of grad students who probably think dark matter is what's in their diapers.

Sheldon: So your solution is to promote me and pay me more money so tha tI can impart my knowledge to the next generation of scientists?
Mrs. Davis: Yes.
Sheldon: You people are sick.

Sheldon: I recently read that during World War Two, Joseph Stalin had a research program to create supersoldiers by having women impregnated by gorillas.
Howard: What a sick use of science.
Raj: Hey, as long as the baby's healthy.
Amy: I wonder if Stalin considered any other animals.
Leonard: Hippos are the deadliest creature. A half-human, half-hippo soldier would be pretty badass.
Howard: Yes, but when they're hungry-hungry, you can stop them with marbles.
Sheldon: Yeah, the correct animal for interspecies supersolider is koala. You would wind up with an army so cute it couldn't be attacked.

As soon as we get home, I want to have coitus with Amy. Okay, she can't hear.

Sheldon: Sherlock Holmes always says when you eliminate the impossible, whatever remains, however improbable, must be the truth. Now, have-have you tried doing that?
Officer Hernandez: Nope.
Sheldon: Well, maybe you should. Th-th-there's lots of books called "Sherlock Holmes" and there's no books called "Officer Hernandez."

Now, typically I wear pajamas, but I recently adopted a hobo lifestyle and pajamas are the sleep-pants of the Man. I'll have you know, Mahatma Gandhi wore no pants and a nation rallied behind him!

Excuse me. Is it at all possible that you're knitting a pair of pants?

Leonard: Sheldon...
Sheldon: Yes?
Leonard: I'm gonna miss you.
Sheldon: Of course you are.
Leonard: He just made that easier.

Penny: He'll be okay. You taught him well, Padawan.
Sheldon: Good Lord! Padawan's the student,
not the teacher.
Penny: Seriously, let him go.

Leonard: So a few things don't go your way and your best decision is to ride the rails like a hobo?
Sheldon: I suppose it is. Except I have a credit card. And I refuse to carry my laptop at the end of a stick. And I'd sooner die than eat beans out of a can.

TBBT Quotes

Oh, Bernadette, please play my clarinet.

Raj's poem

Sheldon: I'll have a diet Coke.
Penny: Can you please order a cocktail? I need to practice mixing drinks.
Sheldon: Fine... I'll have a virgin Cuba Libre.
Penny: That's... rum and Coke without the rum.
Sheldon: Yes, and would you make it diet?