Sheldon: Now, I'm sure you're thinking, "The final episode? Who will stand between us and flag ignorance""
Amy: I know I was thinking that. Is this a show on flags or mind reading?
Sheldon: But the truth is I can no longer balance a full-time career, a popular Internet show, and a girlfriend.
Amy: And he really does have one, you jerks on the comment board. So as they say, all good things must come to an end.

I can't send it back. I had it engraved. "Here lie the ashes of Leonard Hofstadter. He thought he was right, but his roommate knew better."

Leonard: Okay, first of all, the surgery was a success, and secondly, I didn't even want you there.
Sheldon: Wow. I don't know which hurts worse-- my nose or my heart.

Penny: Okay, the reason he deceived you is you were being
a pain in the ass.
Sheldon: The reason I was being a pain in the B is because I was worried about him, and no one else was.
Penny: Really? You won't even say "A"?
Sheldon: You bet your sweet B I won't.

Sheldon: I assume this medical center's already treated the burns on your bottom from the recent pants fire.
Penny: 'Cause I'm a liar, liar?
Sheldon: That's for the fire marshal to determine.

Leonard: If there was an asteroid strike,wouldn't you die, too?
Sheldon: I don't know-- I'm smart and scrappy, I think I'd find a way.

Leonard: Buddy, I-I get that you're worried about me and I-I appreciate that, but I'm not going to die.
Sheldon: You don't know that.
Leonard: Well... I do know that it won't be from an asteroid strike.
Sheldon: You know who else said that? Every cocky T. Rex currently swimming around in the gas tank of your car.

Sheldon: If the surgery is successful, the snoring is gone. And if you die during surgery...the snoring is gone.
Leonard: It sounds like either way, I finally get some rest.

Sheldon: I'm listening to you snore. I'm wondering how I'll ever sleep without it.
Leonard: If it helps you sleep, then why are you sitting here
staring at me like the albino boogeyman?
Sheldon: Really, Leonard-- insults? After I spent two hours in your closet waiting for you to fall asleep?

Sheldon: But you don't have a life-threatening condition. Why would you take the risk of surgery?
Leonard: Sheldon, it's a routine procedure.
Penny: I've heard you complain about his snoring.
Sheldon: We... Yes, for the first five or six years, but I've gotten used to it. It helps me sleep. He's like my mucus-powered white noise machine.

Amy: It's not you. Now think, there's a car named after him.
Sheldon: Of course there is. The Mini Cooper, 'cause it's me.
Amy: How about this: he's a poor man's Sheldon Cooper.
Sheldon: Oh, Tesla.

Whoa, whoa, whoa, whoa. Just because I love you doesn't mean girls are allowed in my room.

TBBT Quotes

Penny: Hey, Sheldon, did you change your Wi-Fi password again?
Sheldon: Yes, it's "Penny, get your own Wi-Fi." No spaces.

Sheldon: Why do you have the Chinese character for "soup" tattooed on your right buttock?
Penny: It's not "soup," it's "courage."
Sheldon: No it isn't. But I suppose it does take courage to demonstrate that kind of commitment to soup.
Penny: How'd you see it? You said you wouldn't look.
Sheldon: Sorry. As I told you, the hero always peeks.