Lois: And lately, this family has been lacking moral fiber, especially you Meg. (Cuts to scene where Meg and Stewie are in living room.)
Lois: Meg! What happened to you?
Stewie: (Sad tone) She can't answer you. She can't even talk. Ever since she started smoking pot, she just kinda lays there. It's really sad. (Happy tone) And a tiny bit funny. Oh my God, I think I'm getting a contact high! (sags like Meg.) Uh, now I'm messed up too.

Brian: Well, we got lucky. How you holding up Stewie?
Stewie: (in female clothing) Ummm, I feel right Brian. I feel right.

Brian: Can you believe that cashier's accent? "Would you like some change for you?"
Stewie: If it weren't for 9/11, they'd be adorable!

Brian: Alright so we roll the dice and then we both have to yell Yahtzee really loud.
Stewie: At the same time?
Brian: Yeah and you have to flap your wrists like this. (Flapping his hands in the air.)
Stewie: And you'll do it to?
Brian: Of course, that's how it's done.
Stewie: Okay.
Brian: Alright, ready?
Stewie: Okay, you going to do it with me?
Brian: Oh yeah.
Stewie: (After Brian throws the dice, screams and flaps his hands.) Yahtzee!
Brian: Gay.
Stewie: You suck!

Stewie: Oh look, an On-The-Raggedy Ann Doll.
(pulls the string)
Doll: It's water weight you bastard!
(pulls the string again)
Doll: Get off me, I'm not your whore!
(pulls the string again)
Doll: (crying) I'm sorry, I'm just so sad.
Stewie: Well, I guess I can still play with it three weeks out of the month.

Peter: Oh boy, does it feel good to undo my butt flap.
Meg: Ew dad! We don't want to sit here and look at your ass.
Stewie: Yes, I'd rather look at Meg toweling off after a shower when she does that butt floss thing. (Cuts to scene where Stewie sees Meg toweling her ass.)
Stewie: (Low voice) Ew, ew, that's so disgusting, uh, uh, uh, I hope I don't ever accidentally use that towel. (Towel falls on Stewie.) Ahhhhh!

Bill Clinton: All right, are you ready for another round of N.A.F.T.A
Lois Griffin: What does N.A.F.T.A. mean?
Bill Clinton: 'Nother Afternoon of F****** That Ass!

(Brian is sitting on the toilet)
Lois: Well, look at you using the toilet. I am so proud of you.
Brian: Hey, well you deserve all the praise for encouraging me to do it.
Lois: Well still, good for you.
(Lois leaves, and Stewie enters)
Stewie: So, where are you really doin' your business?
Brian: Oh, I found a place.
(Scene cuts to Adam West's mansion, he walks near some bushes
Adam West: Well I'll be damned, and they called me crazy; "You can't plant sausage seeds" they said, well look at this!

(After putting two starfish over his nipples) Hey Brian, look, I'm a stripper. I'm working my way through college. I should be more reluctant to take my clothes off, but I'm not because my step-father had boundary issues.

(Brian and Stewie are in the bathroom, staring at the toilet)
Brian: How do you think it works?
Stewie: I have no idea.
Brian: Look, Lois told me I had to start using the toilet, and you're the one who's had potty-training, so I'm counting on you to help me.
Stewie: Alright, we're two intelligent guys, we can figure this out.
(they walk toward the toilet)
Brian: What's that big back part?
Stewie: (nervously) Maybe that's where the wizard lives who operates this thing. It would be wise not to anger him.
Brian: (reaching for the flush handle) I wonder what this thing is for.
Stewie: Brian! Be careful with that, we don't know what it does.
Brian: (sighs) Alright, here goes.
Stewie: Oh god, oh god, careful, careful, careful, careful!
(Brian flushes the toilet, they both run out of the bathroom, Stewie yelling and Brian barking)

Lois: (Enters through front door.) Brian, what is this on my shoe?
Brian: My poop.
Lois: (Takes tissue and wipes shoe.) That's right and it's disgusting. I am sick of you using the front yard as your bathroom. It's time you learn to use the toilet like everyone else.
Stewie: Uh, I'm going to sneeze. I'm going to sneeze. I'm going to sneeze. I'm going to sneeze. (Sneezes on tissue with Brian's poop and looks at it.) Ahhhhh! (Runs away.)

Stewie: Look at Peter in that tank top. He looks more pathetic then when John Merrick went on Match.com.
(Scene of John Merrick having dinner with a woman)
John Merrick: (to his date) There's no way you're a size six!

Family Guy Quotes

Aunt Margarite [on her video will]: Lois, you were always my favorite niece; I just knew you would find a wonderful man who would make all your dreams come true. But I was wrong.
Peter: And now you're dead. Score one for Peter

But now that you mention it, your face looks like a used condom.

Quagmire