Meg: I can't believe my stupid parents are gonna spend five days following stupid old KISS around! It's painful!
Peter: Not half as painful as a tire iron upside your head.
Meg: What?
Peter: I'll miss you!

Peter: You got Legos? Aw, sweet! Lois only buys me Mega Bloks.
Lois: They're the same thing, Peter.
Peter: You know what, Lois? They are not the same thing. And the sooner you get that through your thick skull, the sooner we can get this marriage back on track.

Lois: They cut our school's funding if it's got low test scores? This is not what the founding fathers had in mind. (Cuts to scene to signing of Declaration of Independence.)
Man On Podium: Okay, we're here to sign this declaration of our independence. Let's take roll call first. Thomas Jefferson?
Thomas Jefferson: Here.
Man on Podium: Benjamin Franklin?
Benjamin Franklin: Here.
Man on Podium: John Footpenis?
John Hancock: It's Hancock now.
Man on Podium: Why?
John Hancock: Mind your business, that's why.

Stewie: Because right now, you're about as useless as Black Widow is to the Avengers.
Captain America: So what's your superpower again?
Black Widow: I can kick.
Captain America: Right…so, uh, who else here can kick? Hulk stop being nice.

Hey, I'm not just a poorly-cleaned butt. There's a whole man around man around that you have to please.

Peter

I'm not proud of this, but i'm gonna have to lick that up.

Brian [about puddle of clone]

Peter: I want to have the kind of father and son relationship that the Gumbels have.
Lois: Peter, the Gumbels are brothers.
Peter: Oh nice Lois, just because they're black we can't learn anything from 'em?

Lois: If you kids don't knock it off, we're not goin' to McDonald's after church.
Meg and Chris: MOM!
Peter: Don't worry. We're goin'. B-B-But you don't get the Supersize.
Chris: OH!
Peter: Okay, you can Supersize. But no apple pie!
Meg: Oh, come on!
Peter: Okay, you get an apple pie, but you can't blow on it

I discovered a much more precious element. I discovered dad-mium.

Elijah Wood

Brian: Better luck next time pal, some people got moves, others don't. Been that way forever.
Caveman 1: You. Me. Sex.
Caveman 2: Him legend.

Peter: Guys, be sure to look down the whole time. It's really deep and freaky and disoritenting! [falls] It's okay, there'a huge pile of dead bodies down here that cushioned my fall.
Lois: Do any of them seem like they have any extra tampons in their backpack?
Peter Uh, no.
Lois: No like you checked and there aren't any no, or no you're just assuming?
Peter: I'm embarassed.

Herbert: You like popsicles?
Chris: Well, sure!
Herbert: Then you need to come on down to the cellar. I got a whole freezer full of popsicles. Mmmmm.
Chris: No, thanks. I gotta get going.
Herbert: Oh, don't make me beg now.
Chris: Hahaha! You're funny. Bye.
[Chris pedals away on his bike]
Herbert: Get your fat ass back here

Family Guy Quotes

Aunt Margarite [on her video will]: Lois, you were always my favorite niece; I just knew you would find a wonderful man who would make all your dreams come true. But I was wrong.
Peter: And now you're dead. Score one for Peter

But now that you mention it, your face looks like a used condom.

Quagmire