I bet it itches like you got crabs in there.

Frank [to lady in body cast]

I'm a 60-year-old lady with the vag of a newborn.

Fiona

Fiona: Debbie stole a baby; we have to figure out how to return it.
Lip: Why?
Fiona: It's Debbie.

Oh don't mind me, I accidentally took three of my pills instead of one.

Sheila

Frank: Beautiful day for a party!
Neighbors: It's for kids, Frank. No booze!

That's your teenage diseased mind talking. You tasted penii and now you're just crazy!

Sheila's husband

Do you know why doctors, lawyers and nurses are great liars? Because they lie to help people.

Steve

She was born with a large clitoris!

Frank

I also danced with Cab Calloway, he had the first colored penis I ever kissed.

Fake Aunt Ginger

Well if you need me, I'll be in the bushes across the street stalking you.

Steve

I saw how you looked at Steve like a d-o-g in heat.

Veronica

Holy shit, you popped his cherry? And how was the 30 seconds of bliss.

Veronica

Shameless Season 1 Quotes

Lip: What exactly does hooked up mean?
Kevin: Last I checked penis goes into the vagina.

Surround sound bitching is the only thanks I get.

Frank