I'm cool with jokes about my weight. It's the elephant in the room. That's a joke, too.

Andrea

Compliments after sex? I'm tempted to double your meds and carry you around in my purse.

Rebecca

Cathy: We're gonna cleanse the palette of our affairs. Come on. Do me. It's gonna be great.
Paul: This isn't sexy. It's aggressive and weird.

I, for one, think you're a pretty brave bitch.

Andrea

I never got the Catholic school girl fantasy. Maybe that's because the of actual tragedy being perpetrated against Catholic school boys.

Sean

Marlene really put the nail in the coffin when she, you know, put the nail in the coffin.

Sean

The next time you fire someone on Halloween, you might wanna take off your pointy fucking ears first.

Paul

You have cancer and that pretty much trumps everything all the time!

Paul

My family is blunt, tense and can't relax for shit.

Cathy

We're not soulmates. We're mole mates.

Lee

Soulmate. Not only is it a cliche, it's the reasons millions of women are sitting at home and single.

Cathy

Lee: You're actually my type, Paul.
Paul: Well I'm glad this didn't just get awkward.

The Big C Quotes

Sean: The last you could do is buy a damn Hybrid.
Cathy: The least you could do is take a shower.

Paul: Can we at least figure out what to tell Adam? Because right now, my story is: "Adam, your mom's a meanie!"