Bill Clinton: All right, are you ready for another round of N.A.F.T.A
Lois Griffin: What does N.A.F.T.A. mean?
Bill Clinton: 'Nother Afternoon of F****** That Ass!

[disappointedly] You wanna hurt me? Go right ahead if it makes ya feel any better. I'm an easy target. Yeah. You're right. I talk too much. I also listen too much. I could be a cold-hearted cynic like you, but I don't like to hurt people's feelings. Well, you think what you want about me. I'm not changin'. I like me. My kids like me. My friends like me. 'Cause I'm the real article. What you see is what you get.

"Yes, the penis one."

Fletcher met the long arm of the law at the wrong end of a shotgun at the deep end of a grave at the far end of a dead end road.

Lois: How was your physical, Peter?
Peter: Good. Good. Good, yeah. Too good, as a matter of fact. Ya know what the doctor said? The doctor said I was too healthy. Too good of shape. Don't even know how, too good of shape.
Lois: You didn't go to your physical, did you?
Peter: Er, I did not.

Peter: You've got this all wrong. Like God did when he made Rosie O'Donell.
(cut to scene of a drunk God creating a person)
Angel: You can't put a vagina on this man.
God: And why not? I'm God.
Angel: Well what do you wanna do about the breasts?
God: Take a couple out of the bin we can't find matches for.

Now I may be an idiot, but there's one thing I am not sir, and that sir, is an idiot.

Dennis Miller: I don't wanna go on a rant here, but America's foreign policy makes about as much sense as Beowolf having sex with Robert Fulton at the first Battle of Antietam. I mean when a neo-conservative defenstrates it's like Raskolnikov filibuster deoxymonohydroxinate.
Peter: What the hell does rant mean?

Just last week I let you watch me complain after I ate too many hot wings.

Excuse me, is your refrigerator running? Because if it is, it probably runs like you - very homosexually

I really hope there's a hungry horse back there.

Lois, I'm just warning you, if this movie turns me gay, I'm gonna start bringin' gay guys home. And I don't mean the classy "maybe they are, maybe they're not" gay guys, I mean those big "Oh my God, here they come, floatin' around, makin' noise" gay guys, not the fix up your house gay guys.

Family Guy Quotes

Stewie: (Comes into the bedroom) Lois! Lois! Lois! Lois! Lois! Lois! Mom! Mom! Mom! Mommy! Mommy! Mommy! Mama! Mama! Mama! Ma! Ma! Ma! Ma! Mum! Mum! Mum! Mum! Mummy! Mummy! Mumma! Mumma! Mumma!
Lois: What!?
Stewie: Hi! (Giggling and running out of the room)

How you uh, how you comin' on that novel you're working on? Huh? Gotta a big, uh, big stack of papers there? Gotta, gotta nice little story you're working on there? Your big novel you've been working on for 3 years? Huh? Gotta, gotta compelling protagonist? Yeah? Gotta obstacle for him to overcome? Huh? Gotta story brewing there? Working on, working on that for quite some time? Huh? Yea, talking about that 3 years ago. Been working on that the whole time? Nice little narrative? Beginning, middle, and end? Some friends become enemies, some enemies become friends? At the end your main character is richer from the experience? Yeah? Yeah? No, no, you deserve some time off

Stewie