Dean: Not a word.
Sam: Dude, you just got whaled on by Paris Hilton.

I'm not wearing any makeup. Oh crap. I'm a painted whore.

Zachariah: You're Michael's vessel. Or rather, his receptacle.
Dean: I'm a vessel?
Zachariah: You're the vessel. Michael's vessel.
Dean: How? Why, why me?
Zachariah: Because you're chosen! It's a great honor, Dean.
Dean: Oh, yeah. Life as an angel condom. That's real fun. I think I'll pass, thanks.

What are you, the Hamburglar?

So, what? You're like a DeLorean without enough plutonium.

That's the beauty about improv, Sammy. You never know what's gonna come out of your mouth.

Dean: Really? Anna?
Castiel: It's true.
Dean: So she's gone all Glenn Close, huh? That's awesome.
Castiel: Who's Glenn Close?
Dean: No one. Just this psycho bitch who likes to boil rabbits.
Sam: So, the... the plan to kill me--would it actually stop Satan?
Dean: No, Sam, come on.
Sam: Cass, what do you think? Does Anna have a point?
Castiel: No. She's a... "Glenn Close."

I'm sitting in a laundry-mat, reading about myself... sitting in a laundry-mat reading about myself. My head hurts.

Sam: It's like Grumpy Old Men.
Dean and Bobby: Shut up, Sam!

Michael: And you think you know better than my father? The one unimportant little man. What makes you think you get to choose?
Dean: Because I got to believe that I can choose what I do with my... unimportant little life.
Michael: You're wrong. You know how I know? Think of a million random acts of chance that let John and Mary be born, to meet, to fall in love, to have the two of you. Think of the million random choices that you make--and yet how each and everyone of them brings you closer to your destiny. Do you know why that is? Because it's not random. It's not chance. It's a plan that is playing itself out perfectly. Free will's an illusion, Dean. That's why you're going to say yes.

Dean: Are you wearing glitter?
Kid: I only do it to get laid, man.
Dean: Does it work?

Lucifer: Sorry if it's a bit chilly. Most people think I burn hot. It's actually quite the opposite.
Dean: Well, I'll alert the media.

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean