That's the beauty about improv, Sammy. You never know what's gonna come out of your mouth.

Sam: It's like Grumpy Old Men.
Dean and Bobby: Shut up, Sam!

So, what? You're like a DeLorean without enough plutonium.

[to a demon] You gonna kiss me?

Dean: Oh, come on, you don't trust yourself?
Future Dean: No. Absolutely not.
Dean: Dick.

Dean: You know, it's kind of funny, talking to a messenger of God on a cell phone. It's, you know, like watching a Hell's Angel ride a moped.
Castiel: This isn't funny. Dean. The voice says I'm almost out of minutes.

Dean: Newsflash Mr. Wizard: "vampires pee."

Castiel: We need to talk.
Dean: I'm dreaming, aren't I?
Castiel: It's not safe here... someplace more private.
Dean: More private? We're inside my head.
Castiel: Exactly. Someone could be listening.

Bobby: You are nine kinds of crazy, boy.
Dean: It's been said.

Future Dean: Okay. If you're me... then tell me something only I would know.
Dean: Rhonda Hurley. We were, uh... 19. She made us try on her panties. They were pink. And satiny. And you know what? We kind of liked it.
Future Dean: Touché.

Dean: Try uh, Lautner.
Sam: He's a werewolf. How do you even know who that is?
Dean: What are you kidding me? That kid is everywhere. It's a friggen nightmare.

Dean: Are you kidding me? I have been on red alert about Sam and you come for some stupid horn?
Castiel: You asked me to be here and I came.
Dean: I've been asking you for days you d**k!

Supernatural Quotes

Boy, three bedrooms, two baths, and one homicide. This place is going to sell like hotcakes.

Dean

Dean: Do I know you?
Becky: No, but I know you.