Hello, Penny. I realize that you're currently at the mercy of your primitive biological urges, but as you have an entire lifetime of poor decisions ahead of you, may I interrupt this one

Sheldon: It must be an emergency; everyone at the university knows that I eat my breakfast at 8 and move my bowels at 8:20
Leonard: Yes, how did we live before Twitter?

Sheldon: Why does Leonard get to go?
Wolowitz: Because he's upset over his situation with Penny, and if I have to hear about it again, I'm gonna kick him in his ovaries

I have to say I thought the toilet humor would get less funny with repetition. Apparently there is no law of diminished comedic returns when it comes to space poop

Sheldon: You have to check your messages, Leonard! Leaving a message is one-half of a social contract, which is completed by the checking of the message. If that contract breaks down, then all social contracts break down and we descend into anarchy.
Leonard: It must be hell inside your head.
Sheldon: At times.

Stuart: Here Sheldon. I pulled the new Hellboy for you. It's mind-blowing.
Sheldon: Excuse me! Spoiler alert!
Stuart: What? I didn't spoil anything.
Sheldon: You told me it's mind-blowing, so my mind is going into it pre-blown. Once a mind is pre-blown, it cannot be re-blown.
Stuart: I'm sorry.
Sheldon: Said the Grinch to Christmas.

Leonard: What were you doing at Penny's?
Sheldon: Well, we had dinner, played some games, and then I spent the night. Oh, and you'll be happy to know that I now have a much better understanding of "friends with benefits"

You know, I'm given to understand that there's an entire city in Nevada devoted specifically to help people like Howard forget their problems. They replace them with new problems such as alcoholism, gambling addiction and sexually transmitted diseases

What exactly does that expression mean, "friends with benefits?" Does he provide her with health insurance?

You're probably thinking, "the comic book store, on a Thursday? Why I've fallen down the rabbit hole and into a land of madness." What you have failed to take into account, Penny, is that this is "Anything Can Happen Thursday"

Sheldon: More wrong? Wrong is an absolute state and not subject to degradation
Stuart: It's a little wrong to say to say a tomato is a vegetable, it's very wrong to say it's a suspension bridge

Leonard: I just don't get what she sees in Stuart, we're practically the same guy
Sheldon: ...Stuart is taller, artistic, self employed, and most importantly, gets 45% off comic books

TBBT Quotes

Penny, there's only one cookie with something in the middle that solves life's problems, and that's an Oreo. Or a Nutter Butter, if you're in a pinch.

Sheldon

Penny: Here's a question-- as an alien pretending to be human, are you planning to engage in any post-prom mating rituals with Amy?
Sheldon: There are post-prom mating rituals?
Penny: Not always. Unless your date drives a van with an air mattress, then always.
Sheldon: Well, if it's part of the prom experience, then I'm open to it.
Penny: You're kidding.
Sheldon: I may be an alien, but I have urges.If Amy wants to copulate by firing her eggs into space, well, then, I will happily catch them with the reproductive sac on my upper flermin. I'm not the best at reading facial cues, but I can see that you're a little turned on.