Meg: Mom, can I turn the heat up?
Lois: Don't touch the thermostat, Meg. Your father gets upset.
Meg: Come on. This thing goes up to 90.
[Meg adjusts it a little, and Peter suddenly comes into the room]
Peter: Who touched the thermostat?
Meg: God, how does he always know?
Peter: Brain implant, Meg. Every father's got one. Tells you when the kids mess with the dial.
Guy: My thing went off! Your thermostat okay?

Adam West: Would you answer one question for me?
Psychic: Yes.
Adam West: Thank you so much.

Nigel: Yes, and I'm afraid I'm the limey bastard who's purchased your bar. A bit of an awkward moment, really.
Peter: Awkward moment? I'll give you an awkward moment. One time during sex I called Lois "Frank". Your move, Sherlock

Quagmire: Here's to the Drunken Clam, boys! Where they don't ask for proof of age and neither do I!
Cleveland: Quagmire. You forgot to say "oh".
Quagmire: You sure? I think I did... Well, just to be safe. Oh!

You may have killed her when you shoved all those dollar bills down her throat, you may have killed her when you hit her with the stool... I don't know, I'm not a doctor. But I'll tell you what didn't kill her.... smoking!

Peter

This is a message to all American infidels. Prepare to die in a sea of holy fire. You will be punished for your decadent ways on the first day of Radaman. You...(laughing) Wait, wait a minute. Did I just say? What did I say...Radaman? (stammering) Bla-bla-bla. Ra-ma-dan. Radaman...what is that? Yeah, maybe Dennis Radaman is gonna punish you with his crazy hair.

Bin Laden

Cigarettes killed my father, and raped my mother

Congressman

Stewie: Wow, those are the russian people? I mean granted you do think of bears on unicycles when you think of the russian people, but they're all bears on unicycles?
Dan Aykroyd: Bears on unicycles, every single on of them
Chevy Chase: So what do we do now?
Dan Aykroyd: We're undercover US agents in a hostile foreign environment, we just gotta make sure we don't do anything that makes us stick out
Guard: Hey, they're not bears on unicycles! You're under arrest!

(Peter and Brian are watching TV)
TV Announcer: We now return to Carl Sagan's Cosmos.
TV Announcer 2: Edited for Rednecks.
Carl Sagan: I'm Carl Sagan. Just how old is our planet? Scientists believe it's four bi--
Redneck: (dubbed over) Hundreds and hundreds of years old.
Carl Sagan: Scientists have determined that the universe was created by a s--
Redneck: (dubbed over) God (held long).
Carl Sagan: --ig bang. If you look at the bones of a--
Redneck: (dubbed over) Jesus.
Carl Sagan: --nosaurus Rex, it's clear by the use of carbon dating th--
Redneck: (dubbed over) Mountain Dew is the best soda ever made.

Hey there Mr. Octopus. I see you got two eyes but not much else. We can fix that. (Takes out marker and starts to draw.) Let's give you a nice twiggly little mustache here. And maybe a big ol' dumb guy smiley mouth. And a couple of eyebrows with one raised up like you're saying, 'Say What?' Oh, look whose got pimples... and right before the big dance. (Starts tapping glass with pen and the tank explodes and octopus attacks Peter.)

Peter

Hick Child: Dang it, Buck. It's my turn to use the sex box!
Buck: It's my sex box! And her name is "Sony"

Lois: Peter did you take Stewie to a strip club? he smells like Sweat and fear.
Stewie: Ughh let me tell you Tuesday afternoon is not exactly their "A" squad, I actually saw bullet wounds.

Family Guy Quotes

Aunt Margarite [on her video will]: Lois, you were always my favorite niece; I just knew you would find a wonderful man who would make all your dreams come true. But I was wrong.
Peter: And now you're dead. Score one for Peter

But now that you mention it, your face looks like a used condom.

Quagmire