Lois: I guarantee you a man made that commercial.
Peter: Of course a man made it. It's a commercial Lois, not a delicious Thanksgiving dinner

Joe: Hey neighbors, where's your boat?
Lois: We didn't take the boat, we took the mystery box. Hop in!

Lois: Meg, Could you please change Stewie for me?
Meg: Fine. But if a boy calls, please don't tell them I'm wrist deep in poopy

Peter: What day is it?
Lois: Thursday.
Peter: Oh my God! Oh my God! I'm late!
Lois: If you spent less time fixing your hair...
Peter: No Lois, I'm late, late. Do we still have that pregnancy test?
Lois: Are you insane? You can't have a baby.
Peter: Well I don't have a lot of options. I'm Catholic. I thought you'd be happy

Meg: I don't get it, mom, if you're so mad at dad for wrecking your show, why did you come to opening night?
Lois: I came because I love the theater. I mean, if I just came here to enjoy watching your father be humiliated when this asinine spectacle of his is ridiculed by everyone in town, what kind of person would I be?
Chris: A bitch

Death: What did you make this hot chocolate with? Crap?
Lois: If you want me to make you another, just say so.
Death: I just thought you would make it with milk. Instead of crap

Doctor: This doesn't look good, no this doesn't look good at all.
Lois: Oh no.
Doctor: My nephew drew a picture of me. It doesn't look a thing like me. Look at the nose, it's all wrong!

Death: You gotta kill the kids from Dawson's Creek
Peter: I knew it! As soon as that show came on the air I said, "I'm gonna be the one who has to kill 'em."
Lois: It's true, he really said that

Lois: Peter, who cares how much it is? You've just got the most important bill of all. A clean bill of health.
Peter: Jeez, Lois. How long have you been waiting to crack out that gem?

Lois: I'm so worried about your father.
Chris: You mean because he's a borderline alcoholic?
Lois: No. Mommy's made peace with that.
Chris: Oh, cause he's got a lump on his booby!
Lois: Chris, that's a terrible word! "Booby."
Meg: Mom, Debbie Miller's dad had a lump on his breast, and he turned out okay.
Lois: Really? Who's Debbie Miller?
Meg: A girl I just made up

Peter: Look. Here they are. My family. Guys, I don't say this often enough, but I'm gonna die!
Lois: Oh my god.
Stewie: High five! Anyone? Anyone?

Peter: I'm fine! What are ya, coming on to me now?
Lois: Peter, he's not coming on to you. He's trying to tell you that you're healthy.
Doctor: Can it be both?

Family Guy Quotes

Aunt Margarite [on her video will]: Lois, you were always my favorite niece; I just knew you would find a wonderful man who would make all your dreams come true. But I was wrong.
Peter: And now you're dead. Score one for Peter

But now that you mention it, your face looks like a used condom.

Quagmire