Chris: My dad is smarter than your dad.
Meg: We have the same dad, idiot!
Chris: Yeah, but mine's smarter!

Meg [about Peter being retarded]: I can't believe this is happening to me! I can never go back to school again!
Stewie: Oh, yes, Meg, yes-yes yes, everything was going swimmingly for you until this. Yes, yes, THIS is the thing that will ruin your reputation, not two years of grotesque appearance, or awkward social graces, or that Felix Ungerish way you clear your sinuses, no no no, it's THIS. Do you hear yourself talk? I might kill you tonight!

Meg: Hey, um, do you want to, I don't know, go out sometime?
Craig: Heh, that's about as unlikely as me playing by someone else's rules besides my own, which I would never do. I play by my own rules, nobody else's, not even my own.
Meg: How about a movie?
Craig: I don't go out with dudes

Meg: Mom, Dad, am I ugly?
Lois: Oh, of course not sweetie.
Peter: Yeah, where did you get a stupid idea like that?
Meg: Craig Hoffman.
Peter: Craig Hoff...Craig Hoffman said that? Well he's a sharp kid, you might be ugly

Lois: I'm not comfortable with my daughter being exploited like that.
Meg: Shut up Mom! I want to be exploited

Meg: I wanna watch George Lopez!
Chris: That show only perpetuates the stereotype that George Lopez is funny

Meg: Brian! Chris picked his nose, and now he keeps touching me with finger!
Chris: What good is mining nose gold if I can't share it with the townspeople?

Genie: I am here to grant you three wishes.
Lois: Peter, three wishes. Oh this is so exciting.
Meg: I want a new hat
Chris: I want a new hat
Stewie: I want them to have new hats!

Meg: I can't believe my stupid parents are gonna spend five days following stupid old KISS around! It's painful!
Peter: Not half as painful as a tire iron upside your head.
Meg: What?
Peter: I'll miss you!

Lois: So Meg, did any of the neighbors see Jeff come over?
Meg: Mom! Come one Jeff, let's go in other room.
Lois: Now Meg, no need to get so testes, uh testy. Nuts, I mean crap!

Meg: I'm sure the money clip will be safe in my room.
Stewie: I'm sure it will be lost throughout the pictures of Justin Timberlake or Tom Cruise or ... blast, who the devil do teenagers like ... or Morgan Freeman

Meg: Oh, my God!
Mr. Pewterschmidt: He's violating Seabreeze!
Peter: No, no he's just awkwardly positioning himself--oh now he's violating Seabreeze

Family Guy Quotes

Aunt Margarite [on her video will]: Lois, you were always my favorite niece; I just knew you would find a wonderful man who would make all your dreams come true. But I was wrong.
Peter: And now you're dead. Score one for Peter

But now that you mention it, your face looks like a used condom.

Quagmire