Just as I feared, her Buddhism has led directly to witchcraft.

Flanders [about Lisa]

Lisa: I am interested in learning more about Wicca. Are you a minority group as defined by Ivy League admissions?
Wiccan: Cornell and Dartmouth.

I hate traffic, the band and the phenomenon.

Homer

So now Andy is a TV writer? Loser.

Lisa

Makeup Artist: Andrew, I wanted to show you something in the make out room.. err makeup room.
Andy: I'll be right there in a minute babe. [to Bart]: Looks like I just bought some property on Boner Way.

From now on our family is eating healthy food that looks bad on the shelf and good in our colon.

Marge

Bart: Dad! Lisa's making me see things from both sides again!
Homer: Lisa, I warned you about that!
Lisa: Shouldn't Bart have all the information he needs to make an informed decision?
Homer: Now you're doing it to me, aww...

You know when I was your age, we couldn't film our pranks for Youtube, it was local news or nothing.

Andy Hamilton

Bart: Willie, I know you witnessed the most awesome prank since creation.
Willie: I'll nay speak to you of those dark times, Bart Simpson.
Bart: But if there was a more awesome dude than I, I need to know who he was, what he did and how many days detention he got.

Bart Simpson, that is a rebuilt Yugoslavian engine and there's not even a Yugoslavia anymore. Bring it back at once.

Skinner

My wife and my worst friend. Could it be?

Homer [about Marge and Ned having an affair]

Marge: The most intimate evening we spent this week was when I was ironing your shirts
Homer: Actually, those were Carl's shirts

The Simpsons Season 21 Quotes

Comic Book Guy: You are acceptable!
Homer: Great, would you like to see me naked?
Studio Exec: Oh, there's no nudity in this movie
Homer: What movie?

I played hardball with hollywood, the closest i will ever come to playing a sport in my life

Comic Book Guy