Who designed this thing, NASA!

Dean: You know I finally get why you and dad butted heads so much. You two are practically the same person. I mean I worshipped the guy, y'know: I dressed like him, I acted like him, I listened to the same music. But you are more like him than I will ever be. I see that now.
Sam: I'll take that as a compliment.
Dean: You can take it any way you want.

Castiel: You said "no" to Michael. I owe you an apology.
Dean: Cass. I-It's okay.
Castiel: You are not the burnt and broken shell of a man that I believed you to be.
Dean: Thank you. I appreciate that.
Castiel: You're welcome.

It's like chicks specifically dig unavailable guys.

Danny: You hunt ghosts?
Dean: That's right.
Danny: Like Scooby-Doo?
Dean: Better.

Sam: Dean, enough!
Dean: What?
Sam: You just punched a Cupid!
Dean: I punched a dick!

Dean: You're gonna go out there again?
Sam: Well, crap doesn't hit the fan with coffee breaks.

Dean: All right, everybody stay where you are. You'll be okay.
Jock on Bus: Aren't you the P.E. teacher?
Dean: Not really. I'm like 21 Jump Street. The bus driver sells pot. Yeah.

Sam: You still crazy?
Dean: Not any more than usual.

Sam: Golf? Really?
Dean: It's a ... it's a sport!

What if we win? I'm serious. I mean, screw the angels and the demons and their crap Apocalypse. They want to fight a war, they can find their own planet. This one's ours, and I say they get the hell off of it. We take 'em all on. We kill the Devil. Hell, we even kill Michael if we have to, but we do it our own damn selves.

Dean: Dog: it's what's for dinner.

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean