Lois: Honey, it's not going to go away just because you don't like it.
Stewie: Well then, my goal becomes clear. The broccoli must die!

Lois: Stewie, why don't you play in the other room?
Stewie: Why don't you burn in hell!

Damn you, vile woman! You've impeded my work since the day I escaped from your wretched womb

Stewie: Well, well mother, we meet again.
Lois: Stewie, I thought I tucked you in an hour ago.
Stewie: Not tightly enough it would seem, and now you contemptible harpy, I shall end your oppressive reign of matriarchal tyranny!

Lois: When you were born the doctor said you were the happiest looking baby he'd ever seen.
Stewie: But, of course. That was my victory day. The fruition of my deeply-laid plans to escape from that cursed ovarian bastille!

You know mother, life is like a box of chocolates. You never know what you're going to get. Your life, however, is more like a box of active grenades!

Family Guy Quotes

Aunt Margarite [on her video will]: Lois, you were always my favorite niece; I just knew you would find a wonderful man who would make all your dreams come true. But I was wrong.
Peter: And now you're dead. Score one for Peter

But now that you mention it, your face looks like a used condom.

Quagmire