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Penny: I need some guinea pigs.
Sheldon: Okay, there's a lab animal supply company in Reseda you can try. But if your research is going to have human applications, may I suggest white mice? Their brain chemistry is far closer to ours.
Penny: I swear to God, Sheldon, one day I'm going to get the hang of talking to you.
Leonard: His mom's been saying that for years