Lois: Doctor, do you think the brain tumor could have anything to do with Brian's recent behavior?
Doctor: Hmm, I haven't heard of brains being linked to behavior, but I suppose anything's possible.

Brian: Winning!
Peter: Haha, remember somebody said that?

Chris: Mom, is dad gonna die?
Lois: Well Brian's the one with the brain tumor.

Stewie: Because right now, you're about as useless as Black Widow is to the Avengers.
Captain America: So what's your superpower again?
Black Widow: I can kick.
Captain America: Right…so, uh, who else here can kick? Hulk stop being nice.

I forgot Yelp was a weapon for dumb people, you taught me something today Brian.

Stewie

Stewie: I've been approaching this far too intelligently. He's an idiot, so this shouldn't be hard at all! Hey Brian, you want to go see Doctor Hartman and get that procedure where you get two weiners?
Brian: Whoa, hell yeah! That way when I watch Black Swan, I can aim one at that Natalie Portman, and aim the other one at -
Stewie: Yes, yes, yes, we all know who the other one was.

Brian: I mean I was having fun, making new friends, getting laid all the time, sleeping like a rock - but you made the call. You unilaterally decided I was better off a bitter alcoholic failure who could only hang out with a baby.
Stewie: Hey! We have fun.

I've never even been in a picture before.

Meg

Lois, please send these back to the factory, I believe they're defective.

Peter

I'm gonna take a year off, hit the road, and live life to the fullest!

Stewie

My name's Evan by the way.

Evan

Stewie: Boy in a truck to young to drive
Choir: Sing what you see!

Family Guy Quotes

Aunt Margarite [on her video will]: Lois, you were always my favorite niece; I just knew you would find a wonderful man who would make all your dreams come true. But I was wrong.
Peter: And now you're dead. Score one for Peter

But now that you mention it, your face looks like a used condom.

Quagmire