Brian: The thing is, Meg is becoming a little enamored with me, and I'm kind of losing control of the situation.Lois: Oh she's just grateful you took her to the dance.Brain: Well, uhhh, I..I think its more than that..uhh..so here's the thing..and don't get mad and that part I can't stress enough, that's a great shirt by the way...ummm I may have made out with Meg..(Lois pauses then punches Brian)Brian: (rubbing his nose) Ok I had that coming.Lois: (furious) What the hell is wrong with you, you sick bastard!Brian: (getting to his feet) Look I was drinking..Lois: (sarcastically) Ohhh, what a shock!Brian: (sarcastic laugh) Look the short version is, this morning she made me eat the hair in her pie..(Lois punches Brian again)Brian: (getting up from the ground) No its not what you think, Stewie had some too..(Lois punches Brian again)Brian: (annoyed) Stop punching me!

Lois: Peter, you can't drive a car over that. You're going to get hurt.
Peter: Lois, I don't come down to Burger King and tell you how to do your job.
Lois: Peter, I don't work at Burger...
Peter: I don't work at Burgagagagagaga, I'm busy.

Genie: I am here to grant you three wishes.
Lois: Peter, three wishes. Oh this is so exciting.
Meg: I want a new hat
Chris: I want a new hat
Stewie: I want them to have new hats!

Peter: Lois, I'm packing for Kissstock and I can't find my favorite underwear!
Lois: You mean the one with the hole in the left butt cheek from you tore them pulling them up in the airplane bathroom when you had the trots?
Peter: No, the one with the hole in the right butt cheek from when I held it in during the extra-long sunday service mass because I thought blowing gas would offend Jesus, and I let it go in the vestibule, and it sounded like Louis Armstrong?
Lois: Oh. Middle drawer!

Peter: Everybody, I got bad news - we've been cancelled.
Lois: Oh, no. Peter, how can they do that?
Peter: Well, unfortunately, Lois, there's just no more room on the schedule. We just gotta accept the fact that Fox has to make room for terrific shows like: Dark Angel, Titus, Undeclared, Action, That 80's Show, Wonderfalls, Fastlane, Andy Richter Controls The Universe, Skin, Girls Club, Cracking Up, The Pits, Firefly, Get Real, Freaky Links, Wanda At Large, Costello, The Lone Gunmen, A Minute With Stan Hooper, Normal, Ohio, Pasadena, Harsh Realm, Keen Eddie, The Street, American Embassy, Cedric The Entertainer, The Tick, Louie, and Greg The Bunny.
Lois: Is there no hope?
Peter: Well, I suppose if ALL those shows go down the tubes we might have a shot

Death: You gotta kill the kids from Dawson's Creek
Peter: I knew it! As soon as that show came on the air I said, "I'm gonna be the one who has to kill 'em."
Lois: It's true, he really said that

(Lois is entering the basement holding Stewie)
Stewie: I have so much fun when we hang out Lois, and I love your hair. We should make up a name for your hair color. We could call it like, like strawberry sunset, or ginger maiden. Or or or one of those hair color names thats a random noun, like temptress.
(Lois turns on the Washer)
Stewie: (gasps) Oooh oooh! At some point you have to let me braid it!
(Lois places Stewie into the washing machine)
Stewie: Lois, what are you doing!?
(Lois repeatedly slams the lid on Stewie, and then shuts it)
Stewie: (muffled) ahhhhhh!
(Suddenly, Lois wakes up from what was just a bad dream)
Lois: (Breathing heavily) Oh my god. Oh my god, what's happening to me? I'm like that Texas woman who gave her son brain damage by holding him under water. (gasps) I'm just like Barbara Bush!

Lois: Look Meg, A, Ear sex is just unnatural, and B, how do I say this, vaginal intercourse is...it..its just tops! It's the bee's knees Meg. Oh, when your rattle it around just right, oh my god! I mean, you remember when we had that old car with the bad shocks, and I used to take the old dirt road on purpose! Meg! Meg?
(pans to see Brian in the doorway)
Brian: I love you.

Lois: Glenn, thank you so much for helping me tear up my carpet.
Quagmire: Well ya know Lois, I gotta confess, when you called me, I sort of misunderstood what you were asking for. That's why I rushed over, but it's fine, it's fine, I'm happy to help.

Lois: Peter, I was up all night waiting for you, where were you?
Peter: Where was I? Where were YOU?
Lois: Out drinking. But I got back at two

Lois: Hey Brian... you're home early. What happened with your date?
Brian: Same thing that always happens, she was an idiot

Director [to Lois]: You got a nice wiggle, baby. You wanna be in a movie, huh? A little girl/girl action maybe?
Lois: Peter!
Peter: Good luck buddy, I've been barkin' up that tree for 17 years

Family Guy Quotes

Aunt Margarite [on her video will]: Lois, you were always my favorite niece; I just knew you would find a wonderful man who would make all your dreams come true. But I was wrong.
Peter: And now you're dead. Score one for Peter

But now that you mention it, your face looks like a used condom.

Quagmire