Bianca: You ever streak before?
Frank: Many times. Just never on purpose.

Fuck you! I'm 32, I was just getting started. Fuck you pancreas! Fuck you cells! Fuck you med school! Fuck you!

Bianca

V: I want the old Kev back. The one who looked at me like the world stopped spinning.
Fiona: He's there. He's just preoccupied.

No, just mentally ill.

Ian [to Sammi]

I can't offer you much. But what I can do is be your chauffeur and the limousine ride to the pearly gates.

Frank [to Bianca]

Stick with me woman and you will not go gentle into that good night.

Frank [to Bianca]

You know, you have a choice right now to recognize that you are a promising young college student, not some ghetto outlaw. Stop behaving like the world is out to get you when it is so clearly dropping gifts at your feet. Or you keep doing what you're doing and you end up in a cell somewhere angry and out of options.

Helene [to Lip]

Cuz when you focus on other people's problems, it's a lot easier to ignore your own.

Sean [to Fiona]

Kev: I got nowhere else to go.
Lip: Go home. Hang with your kids. Make up with your wife. It's time.

It's a shame when someone you love gets taken away, isn't it?

Sammi

Bianca: I'm not gonna be alive to pay off my credit card, what does it matter?
Frank: Such wisdom for one so young.

Family sucks ass!

Sammi

Shameless Quotes

Everytime she pees on the stick it's bad news and then I get depressed thinking about my husband banging my mom cause we selfishly wanna have a baby with some of our DNA.

V

Gus: See you at two.
Fiona: Wouldn't miss it.