Peter: I'm home!
Lois: Peter?!
Chris: Dad!
Meg: Daddy!
Stewie: What's your name? Is it Alan?

Lois: Oh by the way Bonnie, we just finished reading the Da Vinci Code at my book club, you were right, its terrific!
Stewie: OH let me guess, some flowery 300 page menopausal, masturbatory aid.

Peter: Me, go to a PTA meeting? What, are you high?
Lois: Nah, not anymore, I crashed hours ago. By the way, we're out of chips, cookies and Funnybones.

Meg: Wow, this looks just like my room at home.
Lois: Yeah except for the all the trophies and pictures of friends.

Lois: I'm gonna become a model!
Peter: Hey that's fantastic Lois, and I'll pleasure myself to your photos.
Chris: Me too!
Meg: Me Too!
Peter: Oh God Meg, that's SICK! That's your mother!
Meg: I'm just trying to fit in.
Peter: Get out, get out of this house!

Lois: I'm gonna go get some oranges, Stewie. Here, hold this bag for Mommy.
Stewie: Oh, what brilliant parenting, Lois, leave a tiny infant with a plastic bag. You know, I just might asphyxiate myself just to teach you a lesson! [attempts to put bag on his head, but fails because it's too large] Here I go, just like that boy from INXS. I'm going to do it...I'm going to do it... [quits] Blast! Good lord, woman, either I was a C-section, or you're Wonder Woman.

Lois: ...like there was a secret hole in me.
Quagmire: Oh God!
Lois: And I was trying to fill that hole with all kinds of expensive objects and things.
Quagmire: Oh Gaaawwwd!
Lois: And I felt wonderful with all those things fillin' that hole.
Quagmire: Oh GAAAAAAAWWWWWWWWWD!
Lois: I did this to myself, so I'm just gonna have to just lay back and let the penal system teach me a lesson.
Quagmire: That one is also sexual.

Lois: That's a great idea, maybe you can join PETA.
Peter: Join me for what?
Lois: No, PETA, the organization.
Peter: What organization?
Lois: PETA.
Peter: what?
Lois: PETA is an acronym, Peter.
Peter: No I'm not, I'm Catholic.
Stewie: Are we really doing this?

You're being silly, Jerome and I dated over twelve inches go.

Lois: My God I can't even react big enough. Here's Mrs. Garret
Mrs. Garret: Whaaat!?
Brian: If my happiness means so little to you that you have Charlotte Rae just standing by to crack a joke then you disappoint me

Brian [about Rita]: Well you met her, what did you think?
Lois: What do I think? She's a 100! Peter, did you see her?
Peter: I'm looking at her now. I can see her from the window up here. Did anyone make a Jessica Tandy joke yet?
Lois: No!
Peter: Awesome! I'll be right down
Chris [to Brian]: Who are you dating, Jessica Tandy?
Peter: Sonuvabitch! Damnit Chris, I called that from upstairs

Meg: Finally! Look Mom I've had it. I'm not babysitting anymore. It's Saturday night I could be out having a life.
Lois: Meg, if you don't wanna baby-sit anymore that's fine, but don't you stand there and lie to me.
Peter: OH-HO Meg, she torched your ass man! She torched your ass

Family Guy Quotes

Aunt Margarite [on her video will]: Lois, you were always my favorite niece; I just knew you would find a wonderful man who would make all your dreams come true. But I was wrong.
Peter: And now you're dead. Score one for Peter

But now that you mention it, your face looks like a used condom.

Quagmire