Charlie: Sure you don't want a drink?
Alan: Nah, when I'm depressed alcohol just makes me feel worse
Charlie: Yeah, same. The trick is to drink past that. It's not a sprint, it's a marathon

Jake: You're cheap.
Alan: I'm not cheap. I'm broke. There's a difference.
Charlie: He was cheap long before he was broke.

Alan: (talking about Milly's mom) She seems nice. Who is she?
Charlie: I have no freaking idea.
Jake: I'll tell you who she is, the grandmother of my children.

There are no such things as small frightened women. That's a myth, perpetrated by the large angry women who secretly run the world!

Charlie

Alan: What's the forecast?
Charlie: High tonight, low tomorrow, 100% chance of hangover.

Alan: You know what they say about nice guys?
Sharon: Yes, they finish last.
Alan: No, they finish in the shower.

Charlie: I gotta figure out a way to get Gail to leave on her own.
Berta: You got the perfect tool for the job.
Charlie: What are you talking about?
Berta: The one tool that's guaranteed to drive any woman out of the house.
Alan [entering the room]: Hello.
Berta: Oh look, it's an Alan wrench.

Confession may be good for the soul, but for marriage, it's a hot, lead enema.

Evelyn

Charlie [about Jake]: If he can score just once before I die then my life will have been worthwhile.
Berta: Then you might want to start eating healthier.

If you can't afford dog food, don't get a dog

Charlie [to Alan about not being in a relationship]

Charlie: I want the good stuff! I want cheese that isn't air-dropped into Third World countries! I want ouchless toilet paper! I want vodka that doesn't look like Fred Flintstone would drink it! I want my life back.
Alan: Fine. Then swallow your pride, call Mom, and ask her to lend you some money.
Charlie [opening the bottle of generic vodka]: Yabba-dabba-doo.

You suggested Charlie's fiancee get small breasts? Why not reinstate prohibition while you're at it?

Evelyn [to Alan]

Two and a Half Men Quotes

Jake: Can I go back to mom's tomorrow?
Alan: Why?
Jake: I want to hang out with my friends.
Alan: What, all of a sudden your father's not good enough for you?
Jake: It's not "all of a sudden."

Alan: Since when do you have a wet suit?
Charlie: Since I moved to the beach and noticed it was full of hot surfer chicks. If I lived next to Jellystone Park I'd have a bear suit and a picnic basket